Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Soy phytoestrogens may block estrogen effects

16.01.2006


Research in monkeys suggests that the natural plant estrogens found in soy do not increase markers of breast cancer risk in postmenopausal women. In fact, they may provide a protective effect in some women. The research is reported today in Cancer Research.



"Even at high doses, we found no evidence that the estrogen-like compounds in soy, called isoflavones, stimulate cell growth or other markers for cancer risk in breast tissue," said Charles E. Wood, D.V.M., Ph.D., lead researcher, from Wake Forest University Baptist Medical Center. "The study also suggests that women who have higher levels of estrogen may actually gain a protective effect from higher doses of soy isoflavones."

Wood said there has been much debate about whether higher levels of dietary soy are safe or beneficial for postmenopausal women. Some evidence has suggested that isoflavones may protect against the more powerful estrogen produced by the body, which is an important risk factor for breast cancer in postmenopausal women. For example, population studies show that women who consume diets high in soy generally have lower rates of breast cancer.


On the other hand, soy isoflavones have been shown to stimulate breast cancer cells in mice and in cells grown in the laboratory.

"Our study sought to make sense of these seemingly contradictory data," said Wood. "Our hypothesis was that estrogen levels in the body may influence the effects of soy isoflavones."

Wood and colleagues evaluated the effects of dietary isoflavones in the presence of different levels of estrogen by rotating 31 postmenopausal cynomolgus monkeys through eight different diets. Each diet contained one of four different isoflavone doses along with either a low or a high dose of estrogen.

Isoflavone doses were equivalent to the following human levels: no isoflavones, 60 milligrams (comparable to the typical Asian diet), 120 milligrams (the highest levels that can be consumed through diet alone), or 240 milligrams (levels obtained through supplements). Estrogen doses were designed to mimic either a low or high-estrogen environment found in postmenopausal women. Estrogen levels in postmenopausal women can vary depending on their amounts of body fat, which produces estrogen, and whether they are taking hormone therapy.

The researchers measured how the diets affected markers for breast cancer risk, including breast cell proliferation. In the low-estrogen environment, no evidence of increased proliferation was seen at any level of isoflavone exposure, even at doses almost several times higher than in a typical Asian diet.

In the high-estrogen environment, there was higher breast cell proliferation both when isoflavones weren’t in the diet and when they were present in lower doses. However, the addition of high levels of dietary soy isoflavones tended to block estrogen effects in breast tissue. This finding suggests that postmenopausal women with higher levels of estrogen may derive the greatest benefit from soy.

"For women at increased risk of breast cancer due to higher estrogen levels, a diet rich in soy isoflavones may offer a modest breast-protective effect," said Wood. However, he said the study may not apply to premenopausal women, who have higher and more dynamic hormone levels, or to women taking combined hormone therapy with an estrogen and a progestin.

The senior investigator of the study was J. Mark Cline, D.V.M., Ph.D. Other researchers involved in the study were Thomas C. Register, Ph.D., and Mary S. Anthony, Ph.D., both from Wake Forest Baptist, and Adrian A. Franke, Ph.D., from the Cancer Center of Hawaii.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Life Sciences:

nachricht Colorectal cancer risk factors decrypted
13.07.2018 | Max-Planck-Institut für Stoffwechselforschung

nachricht Algae Have Land Genes
13.07.2018 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Research finds new molecular structures in boron-based nanoclusters

13.07.2018 | Materials Sciences

Algae Have Land Genes

13.07.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>