A new paper in the January 15th issue of G&D provides the structural basis by which FGF8 splice isoforms (FGF8a and FGF8b) differ in their ability to pattern embryonic brain. FGF8b differs from FGF8a solely by the presence of 11 additional amino acids at its N-terminus.
However, only FGF8b can transform midbrain to cerebellum whereas FGF8a causes an overgrowth of midbrain. Dr. Moosa Mohammadis research team has solved the crystal structure of FGF8b in complex with the FGFR2c receptor, and shows that additional contacts between a single amino acid from the alternatively spliced region of FGF8b with the FGFR2c receptor account for the unique ability of FGF8b to transform midbrain to hindbrain during embryogenesis.
The structural and biochemical data not only provide novel insights into the molecular mechanisms of brain development, but also serves as a framework for examining the role of individual FGF8 isoforms in patterning and development of limb, eye, ear and lung. Moreover, this study is the first to demonstrate that differences in the strength of interaction of closely related growth factors with a common receptor can serve as a regulatory mechanism in cellular signaling.
Heather Cosel | EurekAlert!
Nanobot pumps destroy nerve agents
21.08.2018 | American Chemical Society
How do muscles know what time it is?
21.08.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
21.08.2018 | Medical Engineering
21.08.2018 | Physics and Astronomy
21.08.2018 | Power and Electrical Engineering