The caspase-8 gene plays a critical role in suppressing metastasis (spread) of neuroblastoma, and the expression of this gene is frequently absent in cancer cells that are aggressively metastasizing, according to investigators at St. Jude Childrens Research Hospital and the University of California at San Diego (UCSD). Neuroblastoma is a tumor of the nervous system and is the most common tumor in infants younger than 1 year of age; it accounts for 7-10 percent of childhood cancers.
In the absence of caspase-8 protein, the cell is significantly more capable of escaping from the primary tumor and spreading to other sites in the body, the researchers said. The investigators also showed in laboratory studies that restoring the expression of the caspase-8 gene suppressed neuroblastoma metastases.
The studys findings are significant because they suggest that novel treatments that restore the tumor-suppression role of the caspase-8 gene might prevent the spread of neuroblastoma and improve patient outcome, according to Jill M. Lahti, PhD, an associate member of the Department of Genetics and Tumor Cell Biology. Lahti and David Cheresh, Ph.D., (UCSD) are senior authors of a report on these findings that appears in the January 5 issue of the journal Nature.
Kelly Pery | EurekAlert!
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Life Sciences
16.11.2018 | Life Sciences