Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Transplanted stem cells show promise for mending broken hearts

21.12.2005


Working with heart attack-stricken mice, a team of University of Wisconsin-Madison scientists has shown that embryonic stem cells may one day live up to their clinical promise.



In a paper to be published in the January 2006 issue of the Journal of Molecular and Cellular Cardiology, a team led by UW-Madison stem cell researcher and heart specialist Timothy J. Kamp reports that all-purpose embryonic stem cells, transplanted into mouse hearts damaged by experimentally induced heart attacks, shift gears and morph into functional forms of the major types of cells that compose the healthy heart.

The study’s results are important because they demonstrate that blank-slate embryonic stem cells can be introduced to damaged heart tissue, develop into heart muscle and into cells that form the heart’s blood vessels. If perfected, such therapy could provide a practical, less-invasive alternative to current therapies such as surgery, improve the quality of life for many patients and reduce the number of deaths attributed to heart disease, now estimated at about 700,000 deaths per year in the United States.


"Typically, when that heart muscle dies (as the result of heart attack), it is gone for good," says Kamp, a professor of medicine and physiology in the UW-Madison School of Medicine and Public Health.

In their experiments, when stem cells were introduced directly to tissue damaged by a heart attack, three critical types of cells formed: cardiomyocytes or heart muscle; vascular smooth muscle, the muscle that forms the bulk of the walls of blood vessels; and endothelial cells, the flat cells that line the interior surfaces of blood vessels in the heart and throughout the body’s circulatory system.

"There are multiple components," Kamp explains. "But (in these experiments) we see the three most important types of cells forming. It didn’t completely repair the heart, but it was encouraging."

Kamp emphasized that although results of the new study show promise for using stem cells to repair diseased and damaged tissue, clinical application remains a distant hope. Further studies in mice, primates and, ultimately, humans will be required to ensure efficacy and safety.

Composed mostly of muscle, the heart drives the circulatory system. When it is damaged by a heart attack, scar tissue forms and the heart struggles to do its job of pumping blood throughout the body. With enough tissue damage, congestive heart failure - often leading to death - can occur.

The new experiments were aimed at answering critical questions relative to repairing hearts that have been damaged by heart attacks: Would the cells be driven to repair the heart at the site of the injury, and what kinds of cells would they become?

The group’s finding showed that the cells did indeed migrate to the site of the injury and developed into the critical cell types. Perhaps most importantly, the transplanted cells improved the function of the damaged heart.

"The heart ballooned out less, and its ability to contract improved," Kamp says. "The transplanted cells seemed to respond to the area of active injury. There is something about the injury that favors engraftment and incorporation of those cells."

One intriguing result of the new study is that the implanted cells did not result in tumor formation, one of the primary safety concerns for stem cell therapy. Like cancer cells, embryonic stem cells have a capacity to reproduce indefinitely and scientists must perfect cell transplant methods that are safe before the therapy can be attempted in human patients.

Kamp says future studies will explore ways to refine the cell types used in treating heart disease to enhance safety. His group also plans to implant human cells in mice and non-human primates to further assess the viability of cell transplant therapy and issues of safety.

Timothy J. Kamp | EurekAlert!
Further information:
http://www.medicine.wisc.edu

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>