New research by a team of scientists in France and the United States has identified both the bacterial and host receptor proteins that enable Rickettsia conorii, the Mediterranean spotted fever pathogen to enter cells. Understanding how this bacterium interacts with the cells of its host could lead to new therapeutic strategies for diseases caused by related pathogens, including Rocky Mountain spotted fever and typhus.
Pascale Cossart, an HHMI international research scholar at the Pasteur Institute in Paris, together with her postdoctoral fellow Juan Martinez and collaborators in Paris and at Case Western Reserve University in Cleveland, Ohio, has identified the first receptor for a Rickettsial bacterium. Their findings will be reported in the December 16, 2005, issue of the journal Cell.
Rickettsial bacteria are transmitted by fleas, ticks, and lice to humans and other mammals, where they can cause dangerous and sometimes fatal infections. There are two types of Rickettsial pathogens—the spotted fever group, which includes the Rickettsia conorii bacteria studied by Cossart and her colleagues, and the typhus group. Both must live inside cells to survive. Rickettsia have been classified by the National Institute of Allergy and Infectious Diseases (NIAID) as agents with potential for use as tools for bioterrorism.
Jennifer Donovan | EurekAlert!
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