University and biotech company collaboration prepares MetaChip for technology transfer
This slide includes approximately 2,000 combinations of eight enzymes used in human liver metabolism. To detect toxic drug compound reactions, the slide is “stamped” with a second slide of human organ cells. Photo by RPI/Moo-Yeal Lee and Jonathan Dordick
Recalls of popular prescription drugs are raising public concern about the general safety of new pharmaceuticals. A collaborative group of researchers says that identifying which drug candidates are toxic early in the discovery process can help prevent harmful pharmaceuticals from being placed on the market in the first place, and they have developed a tool to do it.
Researchers at Rensselaer Polytechnic Institute, University of California-Berkeley, and Solidus Biosciences Inc. have developed a biochip, called the MetaChip, which can analyze drug candidates for toxicity and eliminate harmful ones before they advance to pre-clinical stages. Now beginning the second phase of funding for the National Institutes of Health (NIH)-supported project, researchers are working to optimize the technology for the end user: pharmaceutical and biotechnology companies. The researchers are working to bring the MetaChip to market within a year.
Tiffany Lohwater | EurekAlert!
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