Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Getting old? Slowing down? Blame inefficient mitochondria

05.12.2005


Mitochondria are the cell’s equivalent of power stations. A power station burns fuel to build up steam pressure and uses that pressure to drive a turbine linked to a dynamo. This in turn generates electricity. In mitochondria, the fuel is oxidised and builds up a pressure of hydrogen ions (protons). These force through molecular turbines and enable the cell to generate ATP, an energy unit that can be used throughout the cell.



Just as you can work out a power station’s efficiency by seeing how much electricity it produces for each unit of oxygen and fuel it burns, you can assess the efficiency of mitochondria by monitoring the amount of ATP produced for every unit of oxygen used.

Researchers from various departments of the University of Washington, Seattle, compared resting muscle cells from young (7-month) and old (30-month) mice. They found that old muscle used around half as much energy as young muscle, but that the mitochondria used just as much oxygen at both ages. This represents a 50% loss in efficiency.


“The best explanation for this loss of efficiency is that the mitochondria become leaky as they get old. Protons leak back into the mitochondria without making ATP, and so reduce the coupling between oxygen use and ATP production,” says lead author David Marcinek, who works in the department of radiology.

This inefficiency means that elderly people’s muscle produces less useable energy (ATP) for every unit of oxygen consumed, making normal activity seem more challenging and limiting their range of activities.

Carol Huxley | alfa
Further information:
http://www.blackwell-synergy.com/doi/abs/10.1113/jphysiol.2005.097782

More articles from Life Sciences:

nachricht Progress in Super-Resolution Microscopy
17.12.2018 | Julius-Maximilians-Universität Würzburg

nachricht Communication between neural networks
17.12.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data storage using individual molecules

Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.

Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

When a fish becomes fluid

17.12.2018 | Studies and Analyses

Progress in Super-Resolution Microscopy

17.12.2018 | Life Sciences

How electric heating could save CO2 emissions

17.12.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>