Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene Linked With Precursor to Visual Loss

29.11.2005


Gene is associated with increased risk of precursor of macular degeneration



A variant in a gene called Complement Factor H (CFH) appears to contribute to the increased risk of advanced age-related macular degeneration (AMD) largely or entirely through its impact on the development of a precursor of advanced AMD called soft drusen (small yellowish, extracellular deposits of lipid, protein and cellular debris in the back of the eye), according to a multinational team of researchers.

Several research groups recently showed that CFH increases the risk for advanced AMD. However until this study, the relationship between CFH, soft drusen, and advanced AMD was unclear.


In an article to be published online on November 29 by PLoS Medicine, the researchers working at the deCODE genetics Inc., Reykjavik, Iceland, the Moran Eye Center and Eccels Institute of Human Genetics of the University of Utah, USA, and the University of Iceland, found that CFH is a major risk factor for soft drusen. The researchers looked at the CFH gene and its relationship with the presence of soft drusen and AMD in 581 Icelandic patients with advanced and 435 with early AMD, and also 322 US patients with advanced and 109 with early AMD.

AMD is the most common cause of visual loss and is preceded by formation of soft drusen. However, only a portion of patients who develop soft drusen will go on to develop advanced AMD. “We have discovered that the CFH variant is a major risk factor for soft drusen, but does not appear to determine who ultimately progresses to advanced AMD, as previously proposed” , said Dr. Kristinn P. Magnusson, who led the deCODE genetics research team with Dr. Jeffrey Gulcher. Dr. Kang Zhang led the University of Utah team. The authors conclude that it is likely that there are other important genes yet to be found that contribute to the risk of age-related macular degeneration, especially among those who already have soft drusen.

Citation: Magnusson KP, Duan S, Sigurdsson H, Petursson H, Yang Z, et al. (2006) CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med 3(1): e5.

Paul Ocampo | alfa
Further information:
http://www.plos.org
http://dx.doi.org/10.1371/journal.pmed.0030005
http://www.plosmedicine.org

More articles from Life Sciences:

nachricht Colorectal cancer risk factors decrypted
13.07.2018 | Max-Planck-Institut für Stoffwechselforschung

nachricht Algae Have Land Genes
13.07.2018 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Research finds new molecular structures in boron-based nanoclusters

13.07.2018 | Materials Sciences

Algae Have Land Genes

13.07.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>