Duke University Medical Center researchers have found that patients with six specific variants of genes involved in the bodys immune response are significantly more likely to suffer damage of heart tissue after cardiac surgery.
These findings are important because current analytical methods cannot reliably predict who will be likely to suffer from myocardial infarction (MI), or heart tissue death after cardiac surgery. It is estimated that between 7 and 15 percent of patients undergoing coronary bypass surgery will suffer from a subsequent MI, the researchers said.
"We have identified six gene variants, or polymorphisms, that are significantly associated with the incidence of post-operative myocardial infarction following cardiac surgery," said Duke cardiothoracic anesthesiolologist Mihai Podgoreanu, M.D., who presented the results of the Duke study Nov. 13, 2005, during the annual scientific session of the American Heart Association (AHA). The analysis was supported by the National Institutes of Health and the AHA. "Collectively, these variants can explain about 75 percent of the variability in heart damage in patients undergoing surgery."
Richard Merritt | EurekAlert!
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