Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Expression Project for Oncology (expO) collects 1,000th malignant tumor specimen

25.10.2005


Clinically annotated results are publicly available online



The International Genomics Consortium’s (IGC) Expression Project for Oncology (expO) today announced that it has collected its 1,000th frozen cancer specimen, which exceeds original expectations for the project while marking a milestone that is recognized by researchers, industry and academia. Gene expression analysis with clinical information on hundreds of these specimens is now publicly available online.

The purpose of expO is to obtain cancer tissue samples under uniform and standardized conditions, perform gene expression analyses, and collect the long-term clinical outcome of the patient. The data is both collected and shared in a way to ensure the protection of patient confidentiality, while still making the "de-identified" information available online for researchers worldwide. Open and free access to the data will accelerate genetic discoveries and the development of tests and therapies.


"We overcame many challenges to perform complete gene analyses and to have the information freely available online, while also ensuring that we had addressed key issues of patient privacy and consent is a major step forward," said Robert Penny, M.D., Ph.D., Executive Director of expO and Chief Medical Officer of IGC. "Going from zero to 1,000 tumor samples in 16 months was also a considerable feat."

IGC has established a standardization system for obtaining and processing these tumor samples. This standardization of the collection, analysis, and vocabularies will help accelerate future development of new, targeted cancer treatments.

Tissue collection and data dissemination is conducted in a manner that fully protects patient privacy. Over a three-year period, IGC expects to obtain 2,000 to 3,000 tumor specimens representing a broad spectrum of malignancies and 500-1,000 normal tissues. The project is well on its way to meeting this goal. So far, IGC has collected a total of 5,083 biospecimens including frozen biosamples and paraffin tissue blocks containing normal, paranormal and malignant tissue and peripheral blood samples.

"What IGC has accomplished in terms of the expO project could potentially accelerate cancer research," said Franklyn G. Prendergast, M.D., Ph.D., Director of the Mayo Clinic Cancer Center and the Edmond and Marion Guggenheim Professor of Biochemistry and Molecular Biology at the Mayo Medical School. "This publicly available database provides researchers with access to a vast amount of useful cancer information that will ultimately help the community advance its search for new treatments for this devastating disease."

The success of this national philanthropic initiative is due in part to the leadership, vision, and financial support of GlaxoSmithKline, Bristol-Myers Squibb and Wyeth pharmaceuticals.

"The expO database illustrates how industry can partner with academia, hospitals, and non-profit medical research organizations to create a freely available resource that will promote and accelerate discovery.," said Nicholas C. Dracopoli, Ph.D., Vice President of Clinical Discovery Technologies at Bristol-Myers Squibb.

The clinically annotated dataset is available in the public domain through the National Center for Biotechnology Information web site at www.ncbi.nlm.nih.gov/geo/.

Galen Perry | EurekAlert!
Further information:
http://www.tgen.org
http://www.ncbi.nlm.nih.gov/geo/
http://www.intgen.org

More articles from Life Sciences:

nachricht Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

nachricht Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>