Over the past ten years, separate outbreaks of the deadly Zaire strain of Ebola virus (ZEBOV) have killed hundreds of humans and tens of thousands of great apes in Gabon and the Republic of Congo--which harbor roughly 80% of the last remaining wild gorilla and chimpanzee populations. In a new study, Peter Walsh, Roman Biek, and Leslie Real combined genetic data with information on the timing and location of past ZEBOV outbreaks to support the hypothesis that a "consistently moving wave of ZEBOV infection" recently spread to outbreak sites in Gabon and Congo.
Repeated outbreaks of the Zaire strain of the Ebola virus (Ebola virions pictured above) in central Africa were caused by a recent spread of the virus, rather than by a long-persistent strain at each site. (Photo: Walsh et al.)
In the prevailing view, ZEBOV arose from long-persistent local strains after increased contact between humans or great apes and an unidentified reservoir host. But Walsh et al. found support for the alternative hypothesis: that ZEBOV had recently spread to the outbreak regions. This is good news because a virus that spreads at a predictable rate in a predictable direction is far easier to control than one that emerges by chance or at the hands of an unknown trigger. The authors modeled the viruss spread based on assumptions of a long-persistent virus versus a recently emerged virus, and tested the predictions of these competing hypotheses using genetic data--gathered from gene sequences taken from human samples at the different outbreak sites--and information on the spatiotemporal dynamics of the outbreaks.
Though the strength of the individual lines of evidence is not conclusive when considered separately, taken together, they support the view that ZEBOV is spreading as a wave from the first epidemic in Yambuku, Gabon. Following its current course, ZEBOV may hit populated areas east of Odzala National Park within 1–2 years and reach most parks containing large populations of western gorillas in 3–6 years. Two Ebola outbreaks have already hit human populations west of Odzala, and over the past two years, the largest gorilla and chimp populations in the world, found in Odzala, have been devastated--the disease is spreading to the last unaffected sector of the park right now. These findings suggest that strategies to protect villagers and some of the last remaining wild apes from future outbreaks would do best to concentrate efforts at the front of the advancing wave--and start acting now.
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences