A team of researchers at Virginia Commonwealth University Massey Cancer Center has discovered an entirely new mechanism of action for a novel pharmacological agent currently in clinical trials in patients – the kinase inhibitor BAY 43-9006 – which was designed to disrupt the survival pathways of tumor cells.
“This agent was originally designed to inhibit the Raf-1 pathway, which is frequently mutated in many types of cancers, including leukemia,” said Steven Grant, M.D., Massey’s principal investigator for the study that was published in the Oct. 21 issue of the Journal of Biological Chemistry. BAY 43-9006 is a new agent known to induce apoptosis, or cell death, in a variety of tumor cells, presumably by interrupting this pathway. The agent was made available to Massey’s researchers by the National Cancer Institute.
“We were surprised to find that the killing effects of Bay 43-9006 in human leukemia cells had very little to do with inhibition of the Raf-1 pathway,” Grant said. “Instead, the major mechanism of lethality of this compound involved down-regulation of a protein known as Mcl-1, which plays a critical role in protecting leukemic cells from apoptosis.
Small but versatile; key players in the marine nitrogen cycle can utilize cyanate and urea
10.12.2018 | Max-Planck-Institut für Marine Mikrobiologie
Carnegie Mellon researchers probe hydrogen bonds using new technique
10.12.2018 | Carnegie Mellon University
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
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Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
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Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.
The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.
10.12.2018 | Event News
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10.12.2018 | Life Sciences
10.12.2018 | Physics and Astronomy
10.12.2018 | Life Sciences