Chemists and biologists at Northwestern University have found a way to detect and estimate the size and structure of a miniscule toxic protein suspected of triggering Alzheimer’s disease. The findings, researchers say, could help scientists better understand the underlying mechanisms of the disease and lead to the development of new treatments that could slow or possibly arrest its progression.
The findings also could potentially be used to diagnose Alzheimer’s disease in living people instead of during an autopsy, says Amanda J. Haes, Ph.D., a co-author of the study. At present, Alzheimer’s can only be accurately diagnosed after death.
Haes, a National Research Council postdoctoral researcher at the Naval Research Laboratory in Washington, conducted this work while she was a graduate student at Northwestern under the direction of Richard Van Duyne. The findings were presented today at the 230th national meeting of the American Chemical Society, the world’s largest scientific society.
Charmayne Marsh | EurekAlert!
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Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
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Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
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Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
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Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
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