Advances in the molecular modeling and simulation of complex biological systems are enabling researchers to study how certain microbial systems may play an important role in the remediation of contaminated soils. One target is Pseudomonas aeruginosa, a common microbe in sediments and the subsurface. This bacterium is also an important opportunistic pathogen that can cause fatal infections in people with a weakened immune systems.
T.P. Straatsma is leading a team of researchers modeling the lipopolysaccharide outer membrane of P. aeruginosa to learn how the membrane responds to its environment. This research is addressing the question of how this microbe adsorbs to mineral surfaces and what the mechanism is for the uptake and reduction of heavy metals. This has signifi cant implications for bioremediation applications if these metals are radioactive and are reduced to insoluble form to prevent further spreading of the contamination.
In another project, the team also is addressing the health related issues concerning this microbe. Again focusing on the outer membrane, Straatsma and his coworkers are studying the role of a range of proteins embedded in the membrane, as well as the mechanism of action of certain antibiotics that are effective in treating P. aeruginosa infections that plague cystic fi brosis patients, burn victims and patients with compromised immune systems.
Brenda Pittsley | EurekAlert!
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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