Myelodysplastic / myeloproliferative diseases (MDS/MPD) are blood stem cell disorders characterized by ineffective formation and development of blood cells in the bone marrow, resulting in abnormal development of bone marrow precursor cells and a reduction in the number of blood cells. The broad spectrum of symptoms makes MDS/MPD difficult to treat, and there are no good prognostic markers available. No single gene defect has been found for these diseases, and no animal model was available to study them.
A common anomaly associated with these myeloid malignancies is a chromosomal deletion, suggesting the presence of one or more tumor suppressor genes in the long arm of chromosome 20. In a paper appearing online on August 25 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Carlos Martinez-A and colleagues create a new mouse model of MDS/MPD, based on the production of mutant mice in which the Dido gene, mapped to the long arm of human chromosome 20, has been deleted.
The authors also examined human MDS/MPD patients and find 100% of them have Dido expression abnormalities. Furthermore, a substantial number of patients with other hematological myeloid disorders showed significant loss of Dido expression. Thus, Dido might be one of the tumor suppressor genes at chromosome 20q associated with MDS/MPD.
Stacie Bloom | alfa
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
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Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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