Dr. Norbert Perrimon and colleagues at Harvard Medical School (Boston, MA) have used a genome-wide RNAi screen in cultured Drosophila cells to identify novel regulators of the JAK/STAT signaling pathway.
In a stunning example of the utility of cell-based RNAi analysis in a genetically tractable system, like fruit flies, the researchers identified 121 genes involved in the JAK/STAT pathway, including a key, and previously unidentified, negative regulator of the pathway. PTP61F emerged from the screen as the first protein tyrosine phosphatase to inhibit JAK/STAT signaling.
Since the JAK/STAT pathway is conserved between insects and mammals, the authors speculate that many of the new genes that they have identified will turn out to be important to understanding the role of this pathway in both human immune disorders and tumorigenesis.
Heather Cosel | EurekAlert!
Nonstop Tranport of Cargo in Nanomachines
20.11.2018 | Max-Planck-Institut für molekulare Zellbiologie und Genetik
Researchers find social cultures in chimpanzees
20.11.2018 | Universität Leipzig
Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.
Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
19.11.2018 | Event News
09.11.2018 | Event News
06.11.2018 | Event News
20.11.2018 | Life Sciences
20.11.2018 | Life Sciences
20.11.2018 | Physics and Astronomy