Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Development Causes Aging

26.07.2005


Development, the process that gives rise to an adult organism also causes aging, according to Harvard Medical School researchers Joao Pedro de Magalhaes and George Church. Joao Pedro de Magalhaes is a Portuguese microbiologist.

In “Genomes Optimize Reproduction: Aging as a Consequence of the Developmental Program,” appearing in the August issue of the journal Physiology, Joao Pedro de Magalhaes and George Church assert that the aging process is driven by the same genetic processes that drive development.

The idea that development is linked to aging has been frowned upon by scientists for decades, but new evidence demonstrates the two are not only linked but that aging and development are regulated by the same genetic mechanisms. “We now know of several animals that can delay development and as a result delay aging as well,” said lead author de Magalhaes. “Even in mammals there is growing evidence that aging is a consequence of developmental mechanisms. For instance, the pace of development influences the pace of aging, suggesting that the timing of developmental mechanisms determines the timing of aging in mammals.” Hence, the researchers argue that the same genes that regulate the way children grow and develop will later be responsible for their degeneration.



While the same genes drive development and aging, the researchers do not consider that aging is an intentional product of evolution like development. “I don’t think aging is under strong selection,” de Magalhaes said. “What happens, at least in higher organisms like mammals, is that evolution is not about selecting for long life. Evolution is about optimizing developmental mechanisms for reproduction. Once an organism has passed its genes to the next generation evolution gives up on it and the same genes responsible for the growth and maturation of that organism will inadvertently end up killing it. Examples include cell proliferation genes that are crucial in embryonic development but at older ages become harmful and can cause cancer and other age-related diseases.”

One optimistic aspect of this new work is that scientists already know a number of genes regulating development and aging. “Some hormones like growth hormone and genes involved in insulin-like signaling appear to do just that: they regulate growth and development early in life and later contribute to aging. Still,” de Magalhaes warned, “there is a lot of work to be done before we know all the genes involved. Development and aging are so complex that it will be some time before we fully understand them.”

Joao Magalhaes | alfa
Further information:
http://www.med.harvard.edu

More articles from Life Sciences:

nachricht Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex

nachricht New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>