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How bacteria break B cell tolerance

22.07.2005


There is a lot of indirect evidence that microbial infections can initiate and/or worsen autoimmune disease. Autoantibody production during infection results from activation of low-affinity autoreactive B cells. But how this could lead to autoimmune disease is not clear.



In a study appearing online on July 21 in advance of print publication of the August 1 issue of the Journal of Clinical Investigation, Thierry Martin and colleagues from INSERM show in vivo that an experimental infectious disease creates the necessary and sufficient conditions to activate self-reactive B cells with significant affinity. This could drive them to mature into harmful memory B cells and lead to autoimmune diseases in susceptible individuals.

Title: Autoantigen, innate immunity and T cells cooperate to break B cell tolerance during bacterial infection


AUTHOR CONTACT: Martin Thierry, INSERM, Strasbourg, France
Phone: 33(0)390243983; Fax: 33(0)390244016; E-mail: thierry.martin@chru-strasbourg.fr

Stacie Bloom | EurekAlert!
Further information:
http://www.the-jci.org/article.php?id=24646
http://www.the-jci.org

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