Research published in Nature (21 July) will outline for the first time the stem cell origin of the structure of the neck and shoulders in vertebrates. The scientists believe that instead of groups of stem cells creating the skeletal and muscle structure separately they actually appear to make them together as a sort of ‘composite’. This could have significant implications for clinical medicine and our understanding of vertebrate evolution.
Scientists at the Wolfson Institute for Biomedical Research of University College London, part-funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and working with international collaborators, used a new genetic technique to tag embryonic stem cells and then trace them to the adult animal. They discovered that instead of homogeneous groups of stem cells making up the bones of the shoulder and neck and another making the muscles, a newly-discovered group of stem cells called mesenchymal stem cells make both the muscles and the point where it joins the skeleton.
The researchers believe their results show that the skeleton and muscles of vertebrates should not be seen as separate but instead are composites, with the boundaries between cell groups blurred around the body. For example, the stem cell group that makes the connective tissues of the swallowing/gulping muscles also makes the skeletal regions of the shoulder girdle. This sheds new light on human diseases such as Klippel-Feil syndrome where both regions are often malformed.
Matt Goode | alfa
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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