Two common gene variations are associated with the risk for developing chronic kidney disease, according to a study by researchers at the Johns Hopkins Bloomberg School of Public Health and other institutions. One variant increases risk and the other decreases risk with a similar effect in whites, African-Americans, diabetic and non-diabetic individuals. The study, published in the June 15 edition of JAMA, is the first large-scale investigation of the role Apolipoprotein E (APOE) alleles play in chronic kidney disease. APOE is known to be associated with risk of Alzheimer’s disease and heart disease but interestingly, the kidney disease association is in the opposite direction.
Results of the study found that a variant of the APOE gene, the e2 allele, was associated with a moderately increased risk for chronic kidney disease. The study also confirmed that the e4 variant offered protection against the development of chronic kidney disease. The e4 allele is also a known risk factor for Alzheimer’s disease and a weaker risk factor for coronary heart disease. The e2 allele is known to be associated with abnormalities in plasma triglycerides, a condition that is also common with kidney disease. Smaller previous studies have suggested that the e2 increased and e4 alleles decreased the risk of kidney disease, but those studies mostly focused on individuals with diabetes.
"Consistency of association across a number of previous studies is important in convincing us this effect is real. However, our large study suggests that the effect of the APOE gene is much weaker than previous smaller studies indicated," said Josef Coresh, MD, PhD, corresponding author and professor of epidemiology, medicine and biostatistics at the Bloomberg School of Public Health. "Our understanding of the biology and genetics of kidney disease is improved, which may point to directions for future improvements in therapy. However, population screening for kidney disease risk is still best focused on diabetes, hypertension and protein in the urine."
Tim Parsons | EurekAlert!
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
19.07.2018 | Materials Sciences
19.07.2018 | Earth Sciences
19.07.2018 | Life Sciences