Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Understanding DNA drug delivery for lung diseases

07.06.2005


Researchers successfully image delivery and gene expression of DNA nanoparticles into lungs of CF mice



Researchers at the American Society of Gene Therapy Meeting in St. Louis announced that by using imaging technologies, they are able to successfully trace the delivery of DNA nanoparticles and the extent of gene transfer in the lungs of cystic fibrosis (CF) animals. The study represents an important step in developing gene therapy for cystic fibrosis and other serious lung diseases.

Assem Ziady, Ph.D., assistant professor of pediatrics at the Case Western Reserve University School of Medicine, presented the results. He is conducting studies of a promising non-viral DNA nanoparticle technology that may prove to be effective in treating numerous human diseases. For this study, he collaborated with Zhenghong Lee, Ph.D., assistant professor of radiology and an expert in imaging.


In the study, Ziady and colleagues administered to CF mice DNA nanoparticles encoding a gene for an enzyme that produces light when exposed to a particular chemical. Later, the researchers could then use the emitted light to see in real time where the DNA nanoparticles had delivered the gene for expression in the lungs of the mice.

"Development of these real-time imaging modalities has allowed us to better assess the localization and site of activity of our gene transfer complex formulations," said Ziady. "Understanding gene transfer in animals is important in developing nucleic acid-based therapies to treat serious lung diseases such as cystic fibrosis."

The DNA nanoparticle technology is licensed to and being developed by Cleveland-based Copernicus Therapeutics, Inc. "Collaborations with scientists such as Dr. Ziady enable us to better develop nucleic acid therapeutics for different parts of the body and for multiple diseases," said Mark J. Cooper, M.D., senior vice president of Science and Medical Affairs of Copernicus. "Our lead program, which already has had a successful clinical trial, is development of a therapy for the lung complications of cystic fibrosis."

George Stamatis | EurekAlert!
Further information:
http://www.case.edu
http://www.cgsys.com

More articles from Life Sciences:

nachricht First study on physical properties of giant cancer cells may inform new treatments
14.08.2018 | Brown University

nachricht Tiny Helpers that Clean Cells
14.08.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

Im Focus: World record: Fastest 3-D tomographic images at BESSY II

The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.

Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

First study on physical properties of giant cancer cells may inform new treatments

14.08.2018 | Life Sciences

Tiny Helpers that Clean Cells

14.08.2018 | Life Sciences

Algorithm provides early warning system for tracking groundwater contamination

14.08.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>