Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researcher develops compounds to control bacteria

02.06.2005


Without use of antibiotics

A method for controlling bacterial activity without antibiotics by interfering with their communication process has been developed by a young Hebrew University of Jerusalem researcher.

For his work, Adel Jabbour will be presented with a Kaye Innovation Award on June 6 during the 68th meeting of the Hebrew University Board of Governors. Jabbour, a Ph.D. student, conducted his work under the supervision of Prof. Morris Srebnik of the School of Pharmacy and Prof. Doron Steinberg of the Faculty of Dental Medicine. Also working on the project is graduate student Moshe Bronstein



Most human and animal diseases are associated with bacteria that are assembled in "communities," called biofilms, that attach themselves to many surfaces, such as live tissues, implants and teeth. Biofilm can also be found on artificial surfaces such as water pipes or air-conditioning ducts.

Only recently has it been discovered that the bacteria assembled in biofilms have a network of communication between them called "quorum sensing," which controls their collective activity (or lack thereof). These sensing signals control the physiology and pathogenicity of the bacteria in the biofilms. A boron-based molecule that is produced by these bacteria, called auto inducer-2, controls the signals in this quorum sensing process.

Jabbour has succeeded in synthesizing modified chemical compounds, resembling the structure of the natural auto inducer-2, that can disrupt the signaling. By altering the molecular structure in these compounds, Jabbour was able to show that it is possible to control the quorum sensing responses in order to "deceive" the bacteria. The modified compounds distort the signaling that sets off the bacterial changes, making it possible to seriously hamper the bacterial action, or, if so desired, even enhance it (in those cases where the bacteria are beneficial).

Control over quorum sensing provides a promising avenue for future treatment of bacterial pathogenic activity without having to resort to antibiotic drugs with their accompanying disadvantages. On the other hand, enhancing quorum sensing could prove useful in agriculture, biotechnology and the food industry, where increasing bacterial activity would be beneficiary.

A U.S. patent has been filed based on the compounds developed by Jabbour, and further commercialization is being negotiated through the Hebrew University’s Yissum Research Development Company.

Jabbour, 32, lives in Upper Nazareth with his wife Banan, a pediatric resident in at Hadassah University Hospital-Ein Kerem. He is a graduate of St. Joseph High School in Nazareth and obtained his undergraduate degree in chemistry at the Hebrew University and his M.Sc. in pharmacy with honor from the Hebrew University School of Pharmacy. He is currently completing his Ph.D. studies at the School of Pharmacy and the Institute of Dental Sciences at the university under the supervision of Professors Srebnik and Steinberg.

Jerry Barach | EurekAlert!
Further information:
http://www.huji.ac.il

More articles from Life Sciences:

nachricht Small but ver­sat­ile; key play­ers in the mar­ine ni­tro­gen cycle can util­ize cy­anate and urea
10.12.2018 | Max-Planck-Institut für Marine Mikrobiologie

nachricht Carnegie Mellon researchers probe hydrogen bonds using new technique
10.12.2018 | Carnegie Mellon University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

Im Focus: Substitute for rare earth metal oxides

New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals

Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.

Im Focus: A bit of a stretch... material that thickens as it's pulled

Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.

Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...

Im Focus: The force of the vacuum

Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.

The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Expert Panel on the Future of HPC in Engineering

03.12.2018 | Event News

 
Latest News

New method gives microscope a boost in resolution

10.12.2018 | Physics and Astronomy

Carnegie Mellon researchers probe hydrogen bonds using new technique

10.12.2018 | Life Sciences

ETRI exchanged quantum information on daylight in a free-space quantum key distribution

10.12.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>