Scientists have for the first time mapped multiple complex biological interactions in a yeast cell in a simple graphical form, enhancing our understanding of how the networks of interaction by which components of a cell influence one another. New research published in the Open Access journal Journal of Biology shows that such maps can also reveal cryptic interactions and enable accurate predictions about interactions that havent been observed experimentally.
A living cell contains thousands of proteins, genes and macromolecules, enmeshed in complex webs of relationships involving direct or indirect contact. At the simplest level, some recurring patterns of interconnections occur more frequently than expected in randomized networks, and these are called network motifs. Lan Zhang from Harvard Medical School, USA, and colleagues found that the concept of network themes – recurring complex patterns that encompass multiple occurrences of network motifs – allows the building of thematic maps of interactions between macromolecules that can be tied to biological phenomena and may help represent more fundamental network design principles than do simple motifs.
Zhang et al. integrated five different types of biological relationships found in the yeast Saccharomyces cerevisae: protein-protein interactions, genetic interactions, transcriptional regulation, sequence homology and expression correlation. The authors are the first to integrate so many types of data to search for network motifs. The authors conclude that most network motifs found in the integrated S. cerevisae network can be understood in terms of just a few network themes, associated with specific biological phenomena.
Juliette Savin | EurekAlert!
Colorectal cancer risk factors decrypted
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13.07.2018 | Julius-Maximilians-Universität Würzburg
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
13.07.2018 | Event News
13.07.2018 | Materials Sciences
13.07.2018 | Life Sciences