Penn researchers demonstrate that a metabolic enzyme works through the tumor-suppressor protein p53 to control cellular replication
Researchers at the University of Pennsylvania School of Medicine have identified in normal cells that a common metabolic enzyme, which acts as a rheostat of cellular conditions, also controls cell replication. This control is managed through p53, the much-studied protein implicated in many types of cancer. The discovery of the interaction between these two molecules may lead to new ways to fight cancer. First author Russell G. Jones, PhD, a postdoctoral fellow in the laboratory of senior author Craig Thompson, MD, at the Abramson Family Cancer Research Institute at Penn, and colleagues describe their findings in the most recent issue of Molecular Cell.
This work tests the novel notion that cancer cells co-opt cellular pathways that govern metabolism in order to proliferate beyond a cell’s normal means. Cancer cells have, by definition, a high metabolic rate and consume glucose at a high rate. One of the fundamental questions being tested in the Thompson lab is the importance of metabolism in cancer and investigating how cancer cells differ from normal cells, allowing them to survive and replicate. (Thompson is the Chair of Penn’s Department of Cancer Biology and Scientific Director of the Abramson Family Cancer Research Institute.) "We think that the enzyme interprets the energetic environment of the cell," explains Jones. "It senses the stress a cell sees – such as low oxygen, low glucose, or the presence of free radicals – and, from this, can induce a check on replication through p53, acting in effect as a tumor-suppressor."
Karen Kreeger | EurekAlert!
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences