A molecular change that takes place during the progression of malignant brain tumors also occurs in breast cancer, according to a study conducted at Cedars-Sinais Maxine Dunitz Neurosurgical Institute. The shift appears to be part of a process that enables tumors to develop the new blood vessels they need to grow rapidly, migrate and invade other tissue.
Although the switch is evident even in an early stage of breast cancer when cells are proliferating but not infiltrating normal tissue, it becomes more pronounced as the cancer progresses to the invasive stage. Therefore, the genes involved and the proteins they produce may become markers that physicians can use to determine disease progression and patient prognosis. They also may become targets for new therapies.
The switch affects proteins called laminins, which are components of the "basement membrane" of blood vessels, a thin mesh-like structure beneath the cells of the blood vessel surface (epithelium). Although the surface cells and the basement membrane are distinct entities, they affect each other through biochemical interactions. In fact, the cells actually influence the composition of the basement membrane, and the membrane, in addition to serving as a scaffold for cell attachment, regulates cell behavior, proliferation and migration.
Sandy Van | EurekAlert!
How molecules teeter in a laser field
18.01.2019 | Forschungsverbund Berlin
Discovery of enhanced bone growth could lead to new treatments for osteoporosis
18.01.2019 | University of California - Los Angeles
The scientific and political community alike stress the importance of German Antarctic research
Joint Press Release from the BMBF and AWI
The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...
World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles
The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.
Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.
In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...
Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.
It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:
The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...
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18.01.2019 | Health and Medicine