Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drugs targeted at muscle cells

19.04.2005


Can be of use in the treatment of diabetes patients with insulin resistance

Type 2 diabetes is a clinical disease characterised by disruption to the metabolism of glucose and lipids as well as to the production of and physiological reactions to insulin. These disruptions are partly due to a reduced absorption of glucose in the cells that form the body’s fat and muscle tissue. Now scientists at Karolinska Institutet have established that a type of drug targeted at receptors in the muscle cells increases the metabolism and absorption of glucose, making it a potential tool in the treatment of diabetes.

These new findings were published recently in the scientific journal Diabetes. The study has been partly financed with two EU grants from the sixth framework programme (EUGENE2 and EXGENESIS), which were recently awarded to an international network of researchers that includes the authors of the article.



The molecular mechanisms behind Type 2 diabetes are not fully known, but both hereditary and environmental factors are thought to contribute to its development. The prevalence and number of new cases of Type 2 diabetes are steadily increasing in the West, owing, it is thought, to the excessive calorie-rich diets and more sedentary nature of typical Western lifestyles.

The receptors in the muscle cells that were studied are called peroxisome proliferators-activated delta receptors (PFAARä) and they reside in the nucleus where they regulate a large number of enzymes involved in the cell’s metabolism and energy production. Using human muscle cells cultivated in vitro, the researchers were able to show that drugs that bind to PFAARä increase the absorption of glucose in the muscle cells. The two experimental drugs tested in the study were GW501516 and GW0742. The trials demonstrate that the two drugs bind to PFAARä, which triggers a series of reactions within the cells. This, in turn, helps to boost glucose absorption into the cells. By specifically blocking certain processes in the cells, the scientists were also able to show that the effects of the drugs resembled those caused by physical activity. They were also able to show that this was not the result of any effect on insulin signals.

"The discoveries we’ve made are important bearing in mind that one of the problems with insulin therapy for patients with Type 2 diabetes is that they eventually develop a resistance to the insulin and no longer respond to the treatment," say Anna Krook and Juleen Zierath, two of the KI research scientists behind the study. "The PFAARä drugs we have studied, on the other hand, have a direct effect on the cultivated muscle cells and act independently of insulin metabolism. If we can show that the drugs are also effective on living patients, it means that they could one day be used for the treatment of patients who have developed insulin resistance."

Sabina Bossi | EurekAlert!
Further information:
http://www.ki.se

More articles from Life Sciences:

nachricht Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex

nachricht New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>