Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Harnessing microbes, one by one, to build a better nanoworld

18.03.2005


Taking a new approach to the painstaking assembly of nanometer-sized machines, a team of scientists at the University of Wisconsin-Madison has successfully used single bacterial cells to make tiny bio-electronic circuits.

The work is important because it has the potential to make building the atomic-scale machines of the nanotechnologist far easier. It also may be the basis for a new class of biological sensors capable of near-instantaneous detection of dangerous biological agents such as anthrax.

The approach, reported here today (March 17, 2005) at a meeting of the American Chemical Society, suggests that microbes can serve as forms for complicated nanoscale structures, perhaps obviating, in part, the need for the tedious and time-consuming construction of devices at the smallest scale.



The work is also scheduled to appear in the April issue of the journal Nano Letters.

"One of the great challenges of nanotechnology remains the assembly of nanoscale objects into more complex systems," says Robert Hamers, a UW-Madison professor of chemistry and the senior author of the new reports. "We think that bacteria and other small biological systems can be used as templates for fabricating even more complex systems."

Toward that end, Hamers and his UW-Madison colleagues Joseph Beck, Lu Shang and Matthew Marcus, have developed a system in which living microbes, notably bacteria, are guided, one at a time, down a channel to a pair of electrodes barely a germ’s length apart. Slipping between the electrodes, the microbes, in effect, become electrical "junctions," giving researchers the ability to capture, interrogate and release bacterial cells one by one. Built into a sensor, such a capability would enable real-time detection of dangerous biological agents, including anthrax and other microbial pathogens. "The results here are significant because while there has been much attention paid to the ability to manipulate nanoscale objects such as nanotubes and nanowires across electrical contacts, for many applications the use of bacterial cells affords a number of potential advantages," Hamers says.

For example, capitalizing on the complex topography of the bacterial cell surface and microbial interactions with antibodies, scientists could potentially construct much more complex nanoscale structures through the natural ability of cells to dock with different kinds of molecules. Such a potential, Hamers argues, would be superior to the painstaking manipulation of individual nanosized components, such as the microscopic wires and tubes that comprise the raw materials of nanotechnology. "We spend a lot of time making tiny little nanowires and things of that sort, and then we try to direct them in place, but it is very hard," says Hamers. "However, bacteria and other biological systems can be thought of as nature’s nanowires that can be easily grown and manipulated."

In the series of experiments underpinning the new Wisconsin work, the group showed that it is possible to capture cells along an electrode and then direct them down a narrow channel that acts as a conveyor. Small gaps in the electrical contacts along the conveyor serve as traps that can hold single bacterial cells while their electrical properties are measured. Once the microbial interrogation is completed, the live cell can be released. "You can measure and release them at your leisure," explains Beck, the lead author of the Nano Letters paper and a UW-Madison postdoctoral fellow.

He says the chemicals naturally expressed on the surface of the bacterium could be wired in a way that would be the basis for a real-time biological sensor, a device that could be seeded in airports, stadiums, railway stations, skyscrapers, mailrooms and other public areas to sniff for dangerous biological agents that might be used in a bioterror event.

The device could be constructed, according to Beck, utilizing the natural features bacteria and other microbes use to sense their environments. The wired bacterial cells, coupled with modern microelectronics, would have the ability not only to detect dangerous agents (anthrax spores, for example) but they then could sound the alarm and call for help. "You could even engineer bacteria to have different surface molecules that you could capitalize on," says Beck.

For instance, it may be possible, the Wisconsin scientists say, to attach microscopic gold particles to the shell of the bacterium, making it more like a nanoscale gold wire.

Hamers believes the new work could be the basis for bringing nanotechnology and biology together in unprecedented ways.

Moreover, the ability to routinely and easily capture and analyze individual microbes will have implications for conventional biotechnology as well. For example, chemical modifications to the electrode traps might make it easier for scientists to retrieve specified cells from a complex mixture.

The work by Hamers’ group was funded by the National Science Foundation. The Wisconsin Alumni Research Foundation, a private, nonprofit organization that manages UW-Madison intellectual property, has applied for patents for the technology.

The paper on this research, ANYL 424, will be presented at 2:45 p.m., Thursday, March 17, at the San Diego Convention Center, Room 27A, during a symposium titled "Bioanalytical Techniques for Detection of Bacteria, Toxins and Proteins.

Robert J. Hamers | EurekAlert!
Further information:
http://www.wisc.edu

More articles from Life Sciences:

nachricht Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex

nachricht New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>