Developing chemical sensors that can be placed in the bloodstream or under the skin to continuously monitor oxygen, acidity (pH), or glucose levels is a major challenge for analytical chemists and biomedical engineers. The problem is, the body responds to these foreign objects in ways that interfere with their ability to accurately measure blood chemistry. In the bloodstream, clots form on the surface of implanted sensors or blood vessels contract around them. Sensors implanted under the skin may become walled off by cells that flock to the site as part of the inflammatory response.
A University of Michigan team that previously demonstrated improved accuracy with intravascular sensors that were coated with nitric oxide-releasing polymers has promising preliminary results with a new strategy: creating polymer coatings that generate nitric oxide from components already in the blood. U-M chemistry professor Mark Meyerhoff will discuss the work March 15 at the 229th national meeting of the American Chemical Society in San Diego, Calif.
"The idea we had, when we started working on this problem about eight years ago, was to try to mimic what occurs in the human body to prevent clotting on the walls of your own blood vessels," said Meyerhoff. "Your endothelial cells---the cells that line all of your blood vessels---generate nitric oxide. The nitric oxide produced in this layer of cells diffuses back into the blood vessel walls, where it relaxes surrounding muscle cells and increases blood flow. It also diffuses into the lumen of the blood vessel, where it plays another important role: it inhibits platelet function and prevents platelets from sticking to the surface of the blood vessels."
Nancy Ross-Flanigan | EurekAlert!
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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