Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

TGen and Kronos initiate Alzheimer’s disease study

24.02.2005


Researchers have unprecedented chance to search for Alzheimer’s susceptibility genes and develop advanced clinical testing

Phoenix-Researchers at the Translational Genomics Research Institute (TGen) and Kronos Science Laboratories, an affiliate of Phoenix-based Kronos Optimal Health Company, have initiated a study with unprecedented power to identify genes that are involved in the development of Alzheimer’s disease, the most common form of disabling memory and thinking problems in older persons.

Using cutting edge technology, researchers at TGen will survey 570,000 letters of the genetic alphabet (commonly known as "SNPs") in the DNA of 1,000 deceased persons confirmed to have Alzheimer’s disease at autopsy and 1,000 deceased persons confirmed to be free of Alzheimer’s disease at autopsy.



Because of the number of SNPs surveyed-more than any surveyed ever before-researchers have an extraordinary opportunity to search for Alzheimer’s susceptibility genes throughout the human genome. "The technology to sift through the human blueprint at ultra-high resolution to get at the root of diseases such as Alzheimer’s has finally come of age," explains Dietrich A. Stephan, the study’s principal investigator and head of TGen’s Neurogenomics Division. "TGen is one of only a few places in the world that has this type of technology. The collaboration between Kronos and TGen represents a partnership which promises to greatly improve our understanding of the genetic causes of Alzheimer’s disease so we may diagnose it early and develop knowledge-based therapies."

Kronos Science Laboratories will have an exclusive worldwide license to all intellectual property that results from the research. Based upon the results of this study, Kronos will develop a test that aids in clinical diagnosis and can determine a person’s genetic predisposition for developing Alzheimer’s disease. "An estimated 4.5 million Americans are living with Alzheimer’s disease today, and that number is projected to more than triple by 2050," said Dr. Christopher Heward, President of Kronos Science Laboratories. "At Kronos, we are passionate about our healthy living and aging philosophy, and we’re pleased to demonstrate this commitment by participating in this unparalleled study that has the potential to make a significant impact in the lives of affected individuals and families."

To date, researchers have identified several rare genes that cause a form of Alzheimer’s disease resulting in memory and thinking problems before the age of 60. In addition, scientists have identified a common gene that accounts for about 30 percent of those who develop the symptoms of Alzheimer’s disease after the age of 60. The search is now on to discover other genes that contribute to the development of Alzheimer’s disease.

Researchers will obtain DNA samples from brain banks in the USA and Europe.

"We could not be more excited about the possibility of discovering the remaining genes involved in the development of Alzheimer’s disease," says the study’s other principal investigator, Dr. Eric Reiman, Clinical Director of the Neurogenomics Division at TGen, Director of the Arizona Alzheimer’s Disease Consortium, Professor of Psychiatry at the University of Arizona, and Scientific Director of the Positron Emission Tomography Center at Banner Good Samaritan Medical Center. "We hope that this information will improve our understanding of the disorder, provide targets against which to aim new treatments, and permit health care providers to identify those who might benefit from disease-slowing and prevention therapies at the earliest possible time."

The study is expected to cost approximately $6 million and will be jointly funded by TGen and Kronos. Researchers expect the study to be completed within 18 months.

Galen Perry | EurekAlert!
Further information:
http://www.tgen.org
http://www.kronoscompany.com

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>