Coming full circle has new meaning for researchers who demonstrated a promising new approach integrating scientific experimentation and mathematical modeling to study a key signaling pathway that helps cells decide whether to grow or die.
With implications for disease characterization, biotechnology and drug design, the approach tested by researchers at the Medical University of South Carolina (MUSC) and the Georgia Institute of Technology offers an efficient way of gaining useful knowledge from the massive amounts of complex biological information generated with todays advanced analysis technology.
The work represents another step toward modeling complex biological systems accurately enough to make useful predictions. "Our research went beyond describing a one-way street," said Professor Eberhard Voit of the Georgia Tech/Emory University Wallace H. Coulter Department of Biomedical Engineering. "Experimenters generate data, modelers design a mathematical model that fits the data, and often thats the end of the story. But, in this research, the experimenters actually tested hypotheses generated by the model, thus closing the circle."
Jane Sanders | EurekAlert!
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Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
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