Mutations in mitochondrial DNA (mtDNA) play an important role in the development of prostate cancer, according to research by scientists at Emory University School of Medicine and the University of California, Irvine. The findings are published online this week in the Proceedings of the National Academy of Sciences (PNAS). Mitochondrial DNA, which is separate from nuclear DNA, is found in the hundreds of mitochondria located in the cytoplasm outside of each cells nucleus. The mitochondria often are called the "powerhouse" of the cell because they produce about 90 percent of the bodys energy.
John A. Petros, MD, associate professor of urology and pathology at Emory University School of Medicine and the Winship Cancer Institute, and Douglas C. Wallace, PhD, director of the Center for Molecular and Mitochondrial Medicine and Genetics at the University of California, Irvine, sequenced segments of mtDNA from prostate cancer patients and found a variety of mutations, including various mutations in the mtDNA cytochrome oxidase subunit (COI) gene.
They then sequenced the COI gene in 260 prostate cancer tissue samples or blood cells from patients with confirmed cancer who had undergone radical prostatectomies between 1995 and 2002, and 54 tissue samples from patients who had prostate biopsies but were found to be cancer free. Twelve percent of all the prostate cancer samples had mutations in the COI gene, while less than 2 percent of the samples from patients found to be cancer free harbored mutations in this gene. In a control sample of 1,019 individuals from the general population, 7.8 percent had mutations in the COI gene. The researchers found both germ-line (inherited) and somatic (acquired) mutations in the prostate cancer samples.
Holly Korschun | EurekAlert!
Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex
New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences