Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genetic predisposition can play an important role in development of lung cancer

22.12.2004


First-degree relatives of lung cancer patients have a 2 to 3.5 times greater risk of developing lung cancer than the general population, and tobacco smoke plays a major role, even among those with a genetic predisposition, according to a study in the December 22/29 issue of JAMA.



Lung cancer is the leading cause of death from cancer among men and women in many Western countries, according to background information in the article. Death due to lung cancer in the United States exceeds the death rate from breast, prostate, and colon cancer combined. The dominant role of tobacco smoke as a causative factor in lung cancer has been well established. Other studies have indicated that there may be an inherited predisposition to lung cancer, but data have been limited.

Steinn Jonsson, M.D., of the Landspitali-University Hospital, Reykjavík, Iceland, and colleagues examined the contribution of genetic factors to the risk of developing lung cancer in the population of Iceland. The risks for developing lung cancer for first-, second-, and third-degree relatives of patients with lung cancer were estimated by linking records from the Icelandic Cancer Registry (ICR) of all 2,756 patients diagnosed with lung cancer within the Icelandic population from January 1, 1955, to February 28, 2002, with an extensive genealogical database containing all living Icelanders and most of their ancestors since the settlement of Iceland. The risk for smoking was similarly estimated using a random population-based group of 10,541 smokers from the Reykjavik Heart Study who had smoked for more than 10 years. Of these smokers, 562 developed lung cancer based on the patients with lung cancer list from the ICR.


"The nationwide genealogy database used in our study provided a means for uncovering the familial component by revealing more connections between patients, missed in most other populations," the authors write.

The researchers found that a familial factor for lung cancer was shown to extend beyond the nuclear family, as evidenced by significantly increased risks for first-degree relatives (for parents: 2.7 times increased risk; for siblings: 2.02 times increased risk; and for children: 1.96 times increased risk; second-degree relatives (for aunts/uncles: 1.34 times increased risk; and for nieces/nephews: 1.28 times increased risk; and third-degree relatives (for cousins: 1.14 times increased risk) of patients with lung carcinoma. This effect was stronger for relatives of patients with early-onset disease (age 60 or younger at onset) (for parents: 3.48 times increased risk; for siblings: 3.30 times increased risk; and for children: 2.84 times increased risk).

"… this risk ratio [RR] increase in first-degree relatives of patients with lung carcinoma is the result of a combination of environmental, genetic factors, or both. Using genealogy, our study goes further than other reported studies by demonstrating that this familial factor extends beyond the nuclear family as evidenced by significantly increased RR for second- and third-degree relatives of patients with lung carcinoma. In the more distant relationships, shared environmental factors are likely to be of less significance, providing a stronger evidence for genetic factors given that RR is in excess," they write.

"… although the results presented here support a role for genetics in the risk of lung carcinoma, it should be emphasized that tobacco smoke plays a dominant role in the pathogenesis of this disease, even among those individuals who are genetically predisposed to lung carcinoma," the authors conclude.

Edward Farmer | EurekAlert!
Further information:
http://www.jama.com

More articles from Life Sciences:

nachricht During HIV infection, antibody can block B cells from fighting pathogens
14.08.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht First study on physical properties of giant cancer cells may inform new treatments
14.08.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

Im Focus: World record: Fastest 3-D tomographic images at BESSY II

The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.

Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

'Building up' stretchable electronics to be as multipurpose as your smartphone

14.08.2018 | Information Technology

During HIV infection, antibody can block B cells from fighting pathogens

14.08.2018 | Life Sciences

First study on physical properties of giant cancer cells may inform new treatments

14.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>