The overall performance of the gene signature to be used in the first large-scale trial to study the role of such tumor signatures in breast cancer is encouraging and gives the green light to start the trial proper, Dr. Martine Piccart, head of the medical oncology department at the Institut Jules Bordet in Brussels, Belgium, told the San Antonio Breast Cancer conference today (Wednesday 8 December 2004). Dr Piccart heads the TRANSBIG consortium, which intends to use the 70-gene prognostic signature developed by the Netherlands Cancer Institute / Antoni van Leeuwenhoek Hospital (NKI-AVL) in MINDACT, a large, prospective, international randomized clinical trial for lymph node negative breast cancer that will look at the utility of the signature in clinical practice.
TRANSBIG is a translational research network involving 39 partners from all over Europe and Latin America. The validation involved centers in France, Sweden, UK and the US and was based on the frozen archival tumor material of 291 node negative (without cancerous cells in the lymph nodes) patients aged < 60, diagnosed through 1998, and who had received only surgery or radiotherapy. The 70-gene signature outperformed existing standard criteria (St. Gallen, Nottingham Prognostic Index, and Adjuvant Online) in predicting time to distant metastasis (the development of tumors in other parts of the body) and overall survival. The statistical analysis was carried out independently of Amsterdam by a statistical team in Belgium, in collaboration with a bioinformatics group in Switzerland. Dr.Piccart said: "While the overall performance of the 70-gene prognostic signature in the external validation series was inferior to the original Amsterdam series, the results are more than good enough to justify starting the trial."
If the trial confirms that the signature is better than standard methods are in determining which women need chemotherapy after their breast cancer has been surgically removed, it is expected that prescription of such treatment can be reduced by up to 20%. This could have substantial impact on the overall quality of life for many women with breast cancer by reducing side effects, and also the associated health care costs.
Nuria Decker | EurekAlert!
Seeing on the Quick: New Insights into Active Vision in the Brain
15.08.2018 | Eberhard Karls Universität Tübingen
New Approach to Treating Chronic Itch
15.08.2018 | Universität Zürich
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
15.08.2018 | Physics and Astronomy
15.08.2018 | Earth Sciences
15.08.2018 | Physics and Astronomy