Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Publication in Nature: GSF scientists decode the chicken genome

08.12.2004


As members of an international research consortium, a group of GSF scientists led Randolph B Caldwell and Jean-Marie Buerstedde contributed to the annotation of the complete chicken genome. This first genome sequence of a bird is not only of great importance for research projects with chickens, but it will also lead to a better understanding of the previously decoded human genome.



Originally, the GSF research project aimed at identifying active genes in a particularly interesting chicken B cell line DT40. However, when the US Department of Agriculture approved funding for the sequencing of the chicken genome two years ago, an international consortium was rapidly formed by scientists from the USA, Europe and China to coordinate the research activities. While Washington University at St. Louis in the USA sequenced the genome of the Red Jungle Fowl, the ancestor of today’s domestic chicken, the GSF team worked closely with two English groups from Hinxton and Manchester on the definition of the chicken gene sequences. Genes constitute only a small proportion of the genome of vertebrates, but they are extremely important since they determine the amino acid sequences of all proteins and thus the structure and regulatory mechanisms of cells and organs. In the first step, genes in a newly sequenced genome are provisionally identified with the help of computer assisted search programs. In order to test the reliability of the computer predictions, the team from the Institute of Molecular Radiation Biology decided to sequence over new 2000 genes – approximately 10% of the total estimated chicken genes. From the start, the project’s focus was on quality not quantity. Caldwell succeeded in training and motivating 30 work students from the Munich universities to sequence and assemble the gene sequences and then check them by comparing them to known genes from other animals. In addition, thousands of short gene tags were identified in order to verify suspected genes. These investigations showed that the computer generated gene predictions have many inaccuracies, especially at the start and end regions of the genes, which still have to be corrected by follow-up projects.

Michael van den Heuvel | alfa
Further information:
http://www.gsf.de/Aktuelles/Presse/huehnergenom_en.phtml
http://www.gsf.de

More articles from Life Sciences:

nachricht Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>