Biochemists at Ohio State University and their colleagues have overcome one of the major obstacles to drug design, by trimming some of the fat from a molecular sponge that scientists use to study proteins.
In the December issue of the journal Structure, the biochemists report using their method successfully in experiments with two common cellular proteins. The results suggest that scientists could one day use the method as a step in designing drugs for diseases such as cystic fibrosis, Alzheimer’s, and tuberculosis.
Proteins are part of the cell membranes of living organisms, and they are the gatekeepers that regulate what enters and leaves a cell, explained Martin Caffrey, professor of chemistry at Ohio State. To design a drug that will target a particular protein, scientists need to view the protein’s structure in detail, and that involves removing the protein from the cell membrane and forming it into a crystal that can be viewed using x-rays.
Martin Caffrey | EurekAlert!
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Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
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Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
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On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
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