It is tricky enough to get a soccer team of eleven players to cooperate and work as one – but what would it be like if there were 25,000 players on the field? What would the rules be like, and how many referees would it take to make sure that the rules were followed? As it happens, our genomes consist of networks of roughly 25,000 interacting genes, and these networks are obviously very stable and resilient to changed conditions. Out of billions of cells, not a single one falls into chaos. How can order be maintained? A question that scientists have been pondering since the 1960s may now have been answered by theoretical physicists at Lund University, Sweden.
In the most recent issue of the Proceedings of the National Academy of Sciences USA, professor Carsten Peterson and his collaborators Björn Samuelsson and Carl Troein demonstrate how this is possible. The American physician and scientist Stuart Kauffman – a pioneer in the field, who formulated and attempted to solve the problem as early as 1967 – is their co-author.
At any given time, each of the 25,000 genes in a cell may or may not be producing a protein – each gene is on or off, to use language from the world of computers. A gene can affect other genes, turning them on or off. A simple case is that two genes are controlling a third gene. To activate this third gene, both the controlling genes might need to be active, or maybe only one or the other.
Göran Frankel | alfa
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences