Duke University Medical Center geneticists have discovered new proteins that help the olfactory system in mammals organize properly. Thus the proteins are key to the ability of mammals, including humans, to detect and respond appropriately to chemicals in the environment via their sense of smell. The finding in mice paves the way for scientists to unravel the underlying code that allows the brain to interpret smells, according to the researchers.
Using genetic manipulations, the team found two proteins in mice that chaperone odorant receptors to the surface of olfactory nerves in the nose. Odorant receptors are the protein switches nestled in nerve cell membranes that trigger responses to specific volatile chemicals.
The discovery of the chaperone proteins reveals the first molecular components of the olfactory machinery that promotes proper targeting of olfactory receptors to the neuronal cell surface, said Hiroaki Matsunami, Ph.D., assistant professor of molecular genetics and microbiology at Duke. By taking advantage of the newly discovered components of the olfactory machinery, the Duke researchers have already begun tests to match the nearly 1,000 different mouse odorant receptors with the very specific chemical or chemicals to which they respond.
Kendall Morgan | EurekAlert!
Nonstop Tranport of Cargo in Nanomachines
20.11.2018 | Max-Planck-Institut für molekulare Zellbiologie und Genetik
Researchers find social cultures in chimpanzees
20.11.2018 | Universität Leipzig
Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.
Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
19.11.2018 | Event News
09.11.2018 | Event News
06.11.2018 | Event News
20.11.2018 | Life Sciences
20.11.2018 | Life Sciences
20.11.2018 | Physics and Astronomy