Researchers at UT Southwestern Medical Center at Dallas have discovered a protein that controls an early and significant step in the exquisitely timed process of bone formation.
Dr. Eric Olson, chairman of molecular biology, and colleagues have shown the protein HDAC4 to be essential for proper bone development, or osteogenesis. Their findings, reported in the November issue of the journal Cell and available online, may have widespread implications for understanding and preventing osteoporosis or other bone disorders, said Dr. Olson, senior author of the study.
"This was a very unexpected discovery. We were studying the role of the HDAC4 gene in the control of heart growth. When we created genetically modified mice lacking the HDAC4 gene, we found that they had excess bone and died because their cartilage was converted into bone," said Dr. Olson, who directs the Nancy B. and Jake L. Hamon Center for Basic Research in Cancer and the Nearburg Family Center for Basic Research in Pediatric Oncology.
Amanda Siegfried | EurekAlert!
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For the first time, an international team of scientists based in Regensburg, Germany, has recorded the orbitals of single molecules in different charge states in a novel type of microscopy. The research findings are published under the title “Mapping orbital changes upon electron transfer with tunneling microscopy on insulators” in the prestigious journal “Nature”.
The building blocks of matter surrounding us are atoms and molecules. The properties of that matter, however, are often not set by these building blocks...
Scientists at the University of Konstanz identify fierce competition between the human immune system and bacterial pathogens
Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the...
Laser physicists have taken snapshots of carbon molecules C₆₀ showing how they transform in intense infrared light
When carbon molecules C₆₀ are exposed to an intense infrared light, they change their ball-like structure to a more elongated version. This has now been...
The so-called Abelian sandpile model has been studied by scientists for more than 30 years to better understand a physical phenomenon called self-organized...
Physicists from the University of Basel have developed a new method to examine the elasticity and binding properties of DNA molecules on a surface at extremely low temperatures. With a combination of cryo-force spectroscopy and computer simulations, they were able to show that DNA molecules behave like a chain of small coil springs. The researchers reported their findings in Nature Communications.
DNA is not only a popular research topic because it contains the blueprint for life – it can also be used to produce tiny components for technical applications.
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