A study of a recently discovered microRNA gene reveals that its function is to regulate the secretion of insulin in the pancreas. The findings, which for the first time define a biological function for a mammalian microRNA gene, are published in the November 11 issue of Nature.
The discovery was made by a team of researchers from Rockefeller University, Lund University (Sweden), New York University, and Oxford University.
MicroRNA genes are a newly discovered large class of regulatory genes that do not encode proteins. Although these genes are present in virtually all multi-cellular organisms, their biological function had been largely unclear. In the study, microRNA miR-375 was found to regulate insulin secretion. NYUs Nikolaus Rajewsky, a new genomics faculty member in NYUs Center for Comparative Functional Genomics and an assistant professor in the Department of Biology, developed a computer algorithm to predict the targets of microRNAs in the genome. In the study, predicted gene targets for miR-375 were verified experimentally, thereby making an important contribution for understanding miR-375 function in regulating insulin secretion.
James Devitt | EurekAlert!
Scientists uncover the role of a protein in production & survival of myelin-forming cells
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A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
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