Researchers at the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center may have made a crucial discovery in the understanding of cellular aging.
In a study published in the Nov. 1 issue of the Journal of Clinical Investigation, the researchers report that as cells and tissues age, the expression of two proteins called p16INK4a and ARF dramatically increases. This increase in expression, more than a hundredfold in some tissues, suggests a strong link between cellular aging and the upregulation, or increased production, of p16INK4a and ARF.
"At the very least, our work suggests that looking at the expression of one or both proteins will make a great biomarker of aging - a tool to clinically determine the actual molecular age of people, as opposed to just their chronological age," said Lineberger member Dr. Norman Sharpless, the senior author of the study and assistant professor of medicine and genetics at UNCs School of Medicine. "We all know people that we consider to be a young 65, and we believe they wont demonstrate as much p16INK4a or ARF expression as others of the same age."
Leslie H. Lang | EurekAlert!
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Life Sciences