The way that HIV disables the body’s natural defences against retroviruses is not as well understood as recent studies suggest, according to new research published in the Open Access journal Retrovirology. Klaus Strebel and his colleagues from NIH found that the HIV encoded Vif protein does not need to destroy the enzyme APOBEC3G within infected cells to disable it. This latest finding has serious implications for the design of antivirals to fight HIV.
APOBEC3G is one of the most recently identified ways that the body fights off unwanted attacks by retroviruses such as HIV. APOBEC3G is a cellular enzyme with the ability to chemically modify viral genomes and to change their genetic code. The changes to the HIV genome effectively neutralize it and prevent it from spreading to uninfected cells.
Recent research has shown that HIV has found a way to outsmart the body’s attempts to prevent it from replicating. HIV’s viral infectivity factor, or Vif, can prevent the packaging of APOBEC3G into the virus particles, stopping the enzyme from damaging the viral genome. The most popular current working model proposes that Vif does this by destroying APOBEC3G in infected cells.
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences