Painful and damaging chemotherapy may one day be a thing of the past. Researchers at the Georgia Institute of Technology and Purdue University have developed nano-sized particles that can target and trick cancer cells into absorbing them. Once inside, the particles may soon be able to deliver a pharmaceutical payload, killing the tumor from within, avoiding the destruction of healthy cells responsible for much of the damage caused by traditional chemotherapy. The research is published in the August 25 edition of the Journal of the American Chemical Society.
"We’ve developed a class of particles called core/shell nanogels that we can functionalize with a specific kind of chemistry that allows them to target cancer cells,” said L. Andrew Lyon, associate professor at Georgia Tech’s School of Chemistry and Biochemistry.
That specific kind of chemistry is folic acid. Cancer cells have more receptors for folic acid and absorb more of the nutrient than healthy cells. In a process akin to hiding a dog’s heartworm pill in a glob of peanut butter, researchers covered the surface of the nanogels with folic acid, disguising the particles as an essential nutrient. Once the cancer cells took the particles in, researchers increased the temperature of the cells, causing the particles to clump together and shrink, killing the cell.
David Terraso | EurekAlert!
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Joint Press Release from the BMBF and AWI
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The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
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