A team of scientists has found that a protein involved in a congenital neurological disorder also plays a role in DNA damage repair and thus cancer prevention. The research appears as the "Paper of the Week" in the August 13 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.
Primary microcephaly is a rare neurological disorder that results in an abnormally small head due to improper brain formation and growth. Children with this condition may be short, have seizures and have normal or mildly retarded intelligence.
"Microcephalin is the protein encoded by the MCPH1 gene, which, when mutated, is a major cause of microcephaly. We have now identified an important function for microcephalin, which may eventually help explain the connection of MCPH1 with microcephaly, and which links microcephalin function to DNA damage responses that prevent cancer from developing," said David F. Stern, Ph.D., and Xingzhi Xu, M.D./Ph.D. of the Yale University School of Medicine.
Nicole Kresge | EurekAlert!
A novel synthetic antibody enables conditional “protein knockdown” in vertebrates
20.08.2018 | Technische Universität Dresden
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
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08.08.2018 | Event News
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20.08.2018 | Information Technology
20.08.2018 | Life Sciences
20.08.2018 | Information Technology