An enzyme found in nearly all animal and human cells acts as a natural brake to prevent potentially deadly runaway inflammation, UCSF scientists have discovered. The discovery in research with mice suggests a promising target for treating a range of inflammatory diseases in which the bodys immune reaction to bacterial invasion spirals out of control, the researchers report.
The enzyme, known as A20, controls the first step in the series of signals that unleash immune system soldiers against a foreign microbe, the scientists found. The enzymes action, they discovered, blocks signals from pivotal receptors on immune cells, known as toll-like receptors (TLRs), that directly sense the presence of dangerous bacteria and other microbes.
The research shows that A20 prevents over-reactions of the immune system to blood infections known as sepsis -- a life-threatening condition in which bacteria invade the bloodstream. Unchecked by A20, the new research shows, an over-reactive immune response can lead to a deadly collapse of blood pressure. Because bacteria are plentiful in our intestines, the protein may also control the immune reaction that can cause inflammatory bowel disease, the research shows.
Wallace Ravven | EurekAlert!
Nanocages in the lab and in the computer: how DNA-based dendrimers transport nanoparticles
19.10.2018 | University of Vienna
Less animal experiments on the horizon: Multi-organ chip awarded
19.10.2018 | Fraunhofer-Institut für Werkstoff- und Strahltechnik IWS
Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.
Silicon, a so called semiconductor, is currently widely employed for the development of components such as solar cells, LEDs or computer chips. High purity...
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
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