Mayo Clinic researchers have discovered a gene responsible for the onset of aging, including age-related disorders such as infertility, reproductive problems and cataracts. This research, conducted in genetically modified mice, is promising in helping physicians understand and treat the same disorders in humans. The findings appear in the July issue of the journal Nature Genetics. [Baker, D.J. et al. (2004). Nat. Genet. 36, 744-749.
The discoveries came as the result of general investigations into possible genetic causes of cancer. In this case, it was discovered that this particular gene, called BubR1, governs production of a protein that modulates physical aging. The mice studied lacked normal levels of that protein and began to age prematurely.
“Darren Baker in our laboratory found that mutant mice with low amounts of BubR1 protein live five times shorter than normal mice. They also develop a variety of age-related disorders at a very young age,” says lead investigator Jan van Deursen, Ph.D., of the Mayo Clinic Departments of Pediatric and Adolescent Medicine, and Biochemistry and Molecular Biology.
A novel synthetic antibody enables conditional “protein knockdown” in vertebrates
20.08.2018 | Technische Universität Dresden
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
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