Targeting a master molecule that helps cancer cells survive when blood oxygen levels are low may offer a potentially powerful strategy for blocking tumor growth, say researchers at The University of Texas M. D. Anderson Cancer Center.
The molecule, "hypoxia-inducible factor 1," or HIF-1, controls production of a number of other proteins, such as vascular endothelial growth factor (VEGF), which work in concert to help nurture these stressed cancer cells. Researchers show that genetically jamming HIF-1 damages the vascular microenvironment and impairs tumor growth, according to the study, published in the June 16th issue of Journal of the National Cancer Institute.
The resarchers found, for example, that while new blood vessels will still grow in tumors when HIF-1 is blocked, the blood vessels were small, with thin walls, and no lumen -- the passage through which blood flows. The tumors were only about 1/10th the size of cancerous masses seen in a group of control mice.
Laura Sussman | EurekAlert!
Symbiotic upcycling: Turning “low value” compounds into biomass
25.06.2019 | Max-Planck-Institut für Marine Mikrobiologie
New Therapy Promotes Vascular Repair Following Stroke
25.06.2019 | Universität Zürich
From June 25th to 27th 2019, the Fraunhofer Institute for Digital Media Technology IDMT in Ilmenau (Germany) will be presenting a new solution for acoustic quality inspection allowing contact-free, non-destructive testing of manufactured parts and components. The method which has reached Technology Readiness Level 6 already, is currently being successfully tested in practical use together with a number of industrial partners.
Reducing machine downtime, manufacturing defects, and excessive scrap
The quality of additively manufactured components depends not only on the manufacturing process, but also on the inline process control. The process control ensures a reliable coating process because it detects deviations from the target geometry immediately. At LASER World of PHOTONICS 2019, the Fraunhofer Institute for Laser Technology ILT will be demonstrating how well bi-directional sensor technology can already be used for Laser Material Deposition (LMD) in combination with commercial optics at booth A2.431.
Fraunhofer ILT has been developing optical sensor technology specifically for production measurement technology for around 10 years. In particular, its »bd-1«...
The well-known representation of chemical elements is just one example of how objects can be arranged and classified
The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...
Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.
Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...
Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.
The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...
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25.06.2019 | Power and Electrical Engineering
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25.06.2019 | Health and Medicine