Thanks to biophysicists, statistics has reached the most intimate aspect of life – regulation of genes’ activity. Investigation on probabilistic aspects of molecular biology has been supported by the Russian Foundation for Basic Research and the INTAS Foundation.
Regulation of genes’ activity is one of the most important biological problems which has not been solved so far. A cell switches on and off its genes through multiple factors, which, if required, interact with certain sections of a chromosome or vice versa, leave them. While molecular biologists search for the mechanisms than ensure precise and uninterrupted control of genome’s activity, biophysics keep on saying that this is a statistical process, i.e., a probabilistic one, therefore, it cannot be absolutely precise. Specialists of the Engelgardt Institute of Molecular Biology (Russian Academy of Sciences) and the Faculty of Physics, Moscow State University, jointly with the colleagues from the Gumboldt University (Germany) have received equations that allow to assess statistically the regulatory factors/DNA interaction.
According to biophysicists’ opinion, molecules inside the cell move around as freely as in a drop of experimental solution: their concentrations go up and down slightly. Even an insignificant local change in molecule concentration capable of interaction with DNA may impact such interaction. Therefore, if two cells possessing an identical set of genes obviously differ from each other, they owe that to statistical deviations. It is impossible to measure the changes in concentration in experimental systems, therefore the researchers create mathematical models. In fact, these models are sometimes far from real ones (no infinite DNAs or DNAs all set by proteins exist in nature), but they help to evaluate the contribution of fortuity in the sanctum sanctorum of a cell - in regulation of genes’ work. The contribution is significant. Sometimes, due to statistical difference of concentration at the DNA section there may turn out to be eight to twelve regulatory molecules instead of ten. Sometimes, the value of hindrances reaches 17 percent.
Sergey Komarov | alfa
To proliferate or not to proliferate
21.03.2019 | Max-Planck-Institut für molekulare Zellbiologie und Genetik
Discovery of a Primordial Metabolism in Microbes
21.03.2019 | Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH
Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.
The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...
Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.
Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...
The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.
A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...
Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.
"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...
New research group at the University of Jena combines theory and experiment to demonstrate for the first time certain physical processes in a quantum vacuum
For most people, a vacuum is an empty space. Quantum physics, on the other hand, assumes that even in this lowest-energy state, particles and antiparticles...
11.03.2019 | Event News
01.03.2019 | Event News
28.02.2019 | Event News
21.03.2019 | Life Sciences
21.03.2019 | Physics and Astronomy
21.03.2019 | HANNOVER MESSE