Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Once a renin cell, always a renin cell

11.05.2004


In an unusual but useful example of cellular flip-flop, a new research study demonstrates that multiple cell types have the ability to temporarily switch into renin-secreting cells when they are needed to stabilize blood pressure. The research, published in the May issue of Developmental Cell, demonstrates that the recruited cells are direct descendants of cells that expressed renin at one time during development.



Renin is a hormone released into the blood by specialized cells in the walls of kidney blood vessels. Renin is released in response to sodium depletion and/or low blood pressure in the blood vessels of the kidneys and it plays a major role in regulating blood pressure generally in the body. Adult mammals can increase circulating renin, when necessary, by increasing the number of renin-synthesizing cells. Dr. R. Ariel Gomez from the University of Virginia and colleagues examined whether the ability of adult cells to synthesize renin was dependent on the cells’ original lineage. The researchers generated mice with a genetic marker that allowed visualization of renin-expressing cells even after the cell had differentiated into a non-renin-secreting cell type. Experimental manipulations known to recruit renin-expressing cells demonstrated that adult cells that were descendants of renin cells retained the capability to make renin when more of the hormone was required to stabilize blood pressure.

The researchers conclude that specific subpopulations of apparently differentiated cells are "held in reserve" to repeatedly respond by de-differentiating and expressing renin in response to stress and then re-differentiating when the crisis has passed. According to Dr. Gomez, "The experiments confirm that recruitment of renin-expressing cells is determined by the developmental history of the cells, which retain the memory to re-express the renin gene under physiological stress. The mice we have generated should be extremely valuable to delete genes specifically in the renin-expressing cell and therefore determine the precise cellular function of those genes independently of systemic influences."



Maria Luisa S. Sequeira Lopez, Ellen S. Pentz, Takayo Nomasa, Oliver Smithies, and R. Ariel Gomez: "Renin Cells Are Precursors for Multiple Cell Types that Switch to the Renin Phenotype When Homeostasis Is Threatened"

Publishing in Developmental Cell, Volume 6, Number 5, May 2004

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com/

More articles from Life Sciences:

nachricht Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Metal too 'gummy' to cut? Draw on it with a Sharpie or glue stick, science says

19.07.2018 | Materials Sciences

NSF-supported researchers to present new results on hurricanes and other extreme events

19.07.2018 | Earth Sciences

Scientists uncover the role of a protein in production & survival of myelin-forming cells

19.07.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>