A new study shows that the risk for prostate cancer is significantly elevated in men who are part of families with a hereditary form of breast and ovarian cancer. Researchers at Memorial Sloan-Kettering Cancer Center have determined that men in families carrying BRCA genetic mutations have a three- to five-fold increased risk of prostate cancer.
"While the association between hereditary breast and prostate cancer has been suspected, this is the first study of its type to confirm the link," said Kenneth Offit, MD, Chief of the Clinical Genetics Service at Memorial Sloan-Kettering and senior author of the study, which is published in the May 1 issue of Clinical Cancer Research.
Researchers obtained DNA specimens from 251 men of Eastern European (Ashkenazi) Jewish ancestry who had prostate cancer but were otherwise unselected on the basis of personal or family history. The blood samples were tested for mutations of the BRCA1 and BRCA2 genes and compared to specimens taken from 1,472 healthy men. Investigators pinpointed BRCA2 – not BRCA1 – as the common genetic link to prostate cancer.
Esther Carver | EurekAlert!
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A new building material developed at Empa is about to be launched on the market: "memory-steel" can not only be used to reinforce new, but also existing concrete structures. When the material is heated (one-time), prestressing occurs automatically. The Empa spin-off re-fer AG is now presenting the material with shape memory in a series of lectures.
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Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.
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When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
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