Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers confirm genetic link between hereditary breast and prostate cancer

03.05.2004


A new study shows that the risk for prostate cancer is significantly elevated in men who are part of families with a hereditary form of breast and ovarian cancer. Researchers at Memorial Sloan-Kettering Cancer Center have determined that men in families carrying BRCA genetic mutations have a three- to five-fold increased risk of prostate cancer.



"While the association between hereditary breast and prostate cancer has been suspected, this is the first study of its type to confirm the link," said Kenneth Offit, MD, Chief of the Clinical Genetics Service at Memorial Sloan-Kettering and senior author of the study, which is published in the May 1 issue of Clinical Cancer Research.

Researchers obtained DNA specimens from 251 men of Eastern European (Ashkenazi) Jewish ancestry who had prostate cancer but were otherwise unselected on the basis of personal or family history. The blood samples were tested for mutations of the BRCA1 and BRCA2 genes and compared to specimens taken from 1,472 healthy men. Investigators pinpointed BRCA2 – not BRCA1 – as the common genetic link to prostate cancer.


The results show that the frequency of certain BRCA1 and BRCA2 mutations was 5.2 percent in the prostate cancer cases compared to 1.9 percent in the healthy volunteers. When stratified by gene, the risk for prostate cancer was 4.8 times higher in carriers of a specific BRCA2 mutation than in the healthy individuals tested.

"While the participants in the study were of Ashkenazi Jewish ancestry, the results may apply to all individuals with BRCA2 mutations," said Noah Kauff, MD, a gynecologist and geneticist at Memorial Sloan-Kettering and a co-author of the study.

The study authors point out that the age of onset of prostate cancer in men carrying these mutations was no different than in most men diagnosed with prostate cancer in the general population. "Since the age of onset for prostate cancer in men carrying the BRCA2 mutation does not appear to be earlier than in the general population, this would indicate that prostate cancer screening may begin at age 50, as is recommended in the general population, assuming the findings are confirmed in future studies" said Sherri Donat, MD, a urologic surgeon at Memorial Sloan-Kettering and co-author of the study.

The American Cancer Society recommends for men at average risk that prostate cancer screening with serum PSA testing and regular examinations be offered beginning at age 50.

The study’s co-investigators also include Tomas Kirchhoff (first author), Nandita Mitra, Khedoudja Nafa, Helen Huang, Crystal Palmer, Tony Gulati, Eve Wadsworth, Mark Robson, and Nathan Ellis, all of Memorial Sloan-Kettering.


Memorial Sloan-Kettering Cancer Center is the world’s oldest and largest institution devoted to prevention, patient care, research and education in cancer. Our scientists and clinicians generate innovative approaches to better understand, diagnose, and treat cancer. Our specialists are leaders in biomedical research and in translating the latest research to advance the standard of cancer care worldwide.

Esther Carver | EurekAlert!
Further information:
http://www.mskcc.org/

More articles from Life Sciences:

nachricht Molecular motors run in unison in a metal-organic framework
20.03.2019 | University of Groningen

nachricht Active substance from plant slows down aggressive eye cancer
20.03.2019 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Self-healing coating made of corn starch makes small scratches disappear through heat

Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.

Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...

Im Focus: Stellar cartography

The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.

A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...

Im Focus: Heading towards a tsunami of light

Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.

"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...

Im Focus: Revealing the secret of the vacuum for the first time

New research group at the University of Jena combines theory and experiment to demonstrate for the first time certain physical processes in a quantum vacuum

For most people, a vacuum is an empty space. Quantum physics, on the other hand, assumes that even in this lowest-energy state, particles and antiparticles...

Im Focus: Sussex scientists one step closer to a clock that could replace GPS and Galileo

Physicists in the EPic Lab at University of Sussex make crucial development in global race to develop a portable atomic clock

Scientists in the Emergent Photonics Lab (EPic Lab) at the University of Sussex have made a breakthrough to a crucial element of an atomic clock - devices...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Molecular motors run in unison in a metal-organic framework

20.03.2019 | Life Sciences

Active substance from plant slows down aggressive eye cancer

20.03.2019 | Life Sciences

Novel sensor system improves reliability of high-temperature humidity measurements

20.03.2019 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>