Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Embryonic stem cells induced to develop into bone marrow and blood cells

01.04.2004


Researchers at Northwestern University have devised a method to induce embryonic stem cells to develop into bone marrow and blood cells. Injecting the stem cells into the bone marrow cavity of mice whose bone marrow cells had been depleted restored production of blood cells, including cells of the immune system, which normally are created in the bone marrow.



As reported by Richard K. Burt, M.D., and colleagues in April issue of The Journal of Experimental Medicine, the method was effective even in genetically mismatched mice. If the same results can be produced in humans, the technique may eventually eliminate the need to find genetically matched human bone marrow donors for persons with leukemia, autoimmune diseases and other immune disorders, Burt said.

Burt is associate professor of medicine and chief of immunotherapy for autoimmune diseases at the Feinberg School of Medicine at Northwestern University.


Embryonic stem cells, which are derived from embryos, have the potential to grow into many different cell types. Burt and colleagues identified the most effective mix of growth factors to induce stem cells in culture to develop into precursor bone marrow and blood cells. They also developed a technique to select the most viable cells for injection.

Despite the genetic mismatch between donor and recipient mice, the injected cells were not rejected. The injected cells matured into a new immune system that recognized the recipient as self.

Blood or marrow stem cells from a sibling or an unrelated or cord blood registry often fail to develop tolerance to the recipient or patient into which they are infused – an often-fatal complication after bone marrow transplantation that is known as graft-versus-host disease.

But in the study, after embryonic stem cell transplantation the mice’s immune response, while tolerant to self, responded to foreign substances normally, indicating that recipients are able to fight off infection. Although the use of human embryonic stem cell lines is controversial, it has many advantages over the use of donor bone marrow or blood cells, which are highly variable, cannot be cultured in a laboratory, may cause lethal graft-versus-host disease and are often not available to patients due to inability to find a suitably matched donor.

Human embryonic stem cell lines can be cultured indefinitely, providing a permanently renewable alternative marrow source that restores blood cell production with an intact immune response without causing graft-versus-host disease.

Elizabeth Crown | EurekAlert!
Further information:
http://www.nwu.edu/

More articles from Life Sciences:

nachricht Mass spectrometry sheds new light on thallium poisoning cold case
14.12.2018 | University of Maryland

nachricht Protein involved in nematode stress response identified
14.12.2018 | University of Illinois College of Agricultural, Consumer and Environmental Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>